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Open access Sep 2026

The pod components of the Shigella T3SS sorting platform accommodate multiple copies of Spa33 (SctQ)

The bacterial type III secretion system (T3SS) uses a membrane-embedded injectisome assembly to export effector proteins into host cells. While atomic-level structural details have been revealed for much of the T3SS apparatus, the model of the cytoplasmic sorting platform remains largely low-resolution. A central struc...

Sean K. Whittier, Shoichi Tachiyama, Samira Heydari et al. · 0 citations
Open access Jul 2026

Near-atomic in situ architecture and membrane-coupled dynamics of the Vibrio cholerae sheathed flagellum

The sheathed flagellum of Vibrio cholerae is a self-assembling membranous organelle that coordinates flagellar assembly, sheath biogenesis, and rapid rotation. Here, we determine in-situ near-atomic structures of the sheathed flagellar motor within intact cells. The motor anchors to the outer membrane through lipidated...

Wang-Biao Guo, Jian Yue, Jin Hwan Park et al. · 0 citations
#protein folding Aug 2026

The human papillomavirus L2 protein in the capsid is an ensemble of related structures poised to exit the virus particle

A structural model of L2 within the capsid is developed using cryo-EM single particle analysis of HPV16 pseudovirus capsids with and without the L2 protein combined with AlphaFold3 predictions and molecular dynamics simulations to develop a structural basis for understanding how L2 is organized in the capsid poised to...

Changin Oh, Huaxin Yu, Patrick M. Buckley et al. · 0 citations

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