Jundan Tian

A transferable perturbation proteomics framework for phenotype- 1 based annotation and antiproliferative potency scoring of antineoplastic agents

Although antineoplastic agents target diverse proteins, whether they converge on conserved cellular response states remains unclear. Here, we generate a TMTpro 18-plex quantitative proteomics atlas of 367 antineoplastic agents in HepG2 cells and identify recurrent drug response phenotypes (DRPs). The higher-order organ...