Author

Junyu Zhou

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Open access Oct 2026

Bifidobacterium longum Depletion and Bile Acid Dysregulation in MASLD: Links to Hepatic TGR5–AMPK Signaling

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide. Although gut microbiota dysbiosis and aberrant bile acid metabolism are central to MASLD pathogenesis, the critical keystone species and precise molecular mechanisms remain elusive. Here, we performed an...

Shao-Jun Li, Wen-Xiang Sheng, Yang Yang et al. · Microorganisms · 0 citations

#gene editing Review Open access Jul 2026

Evolving Landscape of Systemic Therapy for Hepatocellular Carcinoma: From Targeted Therapy and Combination Strategies to Emerging Therapies

Background: Hepatocellular carcinoma (HCC) is the predominant histological subtype of primary liver cancer, and many patients with unresectable disease require systemic therapy. This narrative review asks how current systemic regimens should be selected and sequenced, how oncogenic pathways inform resistance and biomar...

Hui Li, Junyu Zhou, Xu Zhu · Biomedicines · 0 citations