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Jürgen G. Haas

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#gene editing Open access Sep 2026

mRNA editing of the Alzheimer’s risk gene APOE

It is reported that APOE mRNA is enzymatically edited to convert E4 to E3/E2, and/or E2 to E3/E4, and up to ∼10% conversion was seen in brain, and up to 100% in vitro driven by the RNA-editing enzyme APOBEC1.

Valérie Blanc, Samantha J. Griffiths, Jürgen G. Haas et al. · bioRxiv · 0 citations