Biological reducing power is carried by nicotinamide adenine dinucleotide (phosphate) (NAD(P)/H), which supports cellular functions and cannot be specifically directed to engineered metabolic pathways. Nicotinamide mononucleotide (NMN(H)) has emerged as an orthogonal redox cofactor to address this. Herein, to create...
Yu Ping, Jin Young Kim, Minh-Anh L. Dinh et al.· Nature Communications· 0 citations
Noncanonical redox cofactors (NRCs) are low-cost alternatives to the natural redox cofactors nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+) for biomanufacturing, offering exquisite electron-delivery control, yet their adoption is limited by the scarcity of compatible en...
Samer Saleh, Ning-Hsiang Hsu, Emma Luu et al.· Nature Chemical Biology· 0 citations
Native amino sugar biosynthesis in E. coli provides a controllable framework for producing chemically distinct sugars through endogenous metabolism and establishes a generalizable strategy for engineering amino sugar and other nitrogen-containing metabolite biosynthesis.
Dileep Sai Kumar Palur, Amey Bait, Bryant Luu et al.· Metabolic Engineering· 0 citations
Together, these results establish a scalable strategy for accessing previously unexplored Rubisco sequence space, providing a broadly accessible path toward generating de novo Rubiscos that have activity and specificity parameters needed to address longstanding limitations in biological carbon fixation.
Alexander J. Kehl, Simon K. S. Chu, J. H. Pereira et al.· bioRxiv· 0 citations
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