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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

K. Alexandrov

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Open access Oct 2026

Structure-Guided Discovery of High-Affinity Methotrexate Aptamers for Electrochemical Drug Monitoring

Methotrexate (MTX) is a narrow-therapeutic-index drug widely used in cancer and autoimmune disease treatment, for which delayed clearance can cause severe toxicity and requires close therapeutic drug monitoring. Here, we integrate high-stringency Capture-SELEX, biophysical characterization, molecular modeling, mutation...

Micaela B. Sequera, Thiago C. Pimenta, Rafael Vieira et al. · 0 citations
#protein folding Open access Oct 2026

Conformation-Selective Binding Domains of Intramolecular Chemically Induced Protein Dimerisation Systems.

It is demonstrated that CID systems can be used as building blocks for higher-order ligand-controlled protein systems and established a generalisable strategy for harnessing the affinity gains of intramolecular CID systems to create gain-of-signal assays for small molecules and ions.

Zhen-Ling Cui, Zhong Guo, Y. Liew et al. · 0 citations

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