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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

K. Brennand

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Open access Sep 2026

Spared corticospinal neurons activate an endogenous plasticity program after partial CNS injury

Functional recovery after incomplete spinal cord injury depends substantially on the capacity of anatomically spared neurons to remodel their connections, yet the molecular programs underlying this endogenous plasticity remain poorly understood. To identify and validate these mechanisms, we combined retrograde labeling...

M. Murillo, Ciara F. O'Brien, Noa Golan et al. · 0 citations

Systematic Dissection of Key Driver Perturbation Signatures in Single Cells via ECCITE-seq.

An ECCITE-seq framework is described to characterize the transcriptomic consequences of perturbing multiple neuronal key driver genes associated with Alzheimer's disease (AD) in human-induced pluripotent stem cell (hiPSC)-derived neurons and allows for the assessment of the regulatory impact of candidate genes implicat...

Jing-Long Zhang, K. Brennand, Bin Zhang et al. · 0 citations
#gene editing Open access Sep 2026

Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency

The results reveal a unique human mechanism of disease and offer therapeutic insight for this inflammasomopathy and CRISPR editing of human CD34+ hematopoietic stem and progenitor cells (HSPCs) led to very efficient and persistent gene deletion in vivo.

Tian-Li Xiao, J. R. Brewer, Maximillian J. Carlino et al. · 0 citations

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