Author

K. L. Nielsen

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Open access Sep 2026

Resistance to antibacterial peptide nucleic acids through altered ribosome function

The ribosome–mRNA interface is identified as an intracellular determinant of antibacterial PNA susceptibility and rpsLI82N alters uS12-dependent 30S assembly and initiation-complex dynamics, thereby changing the effective occupancy of mRNA translation-initiation regions.

J. Frimodt-Møller, I. M. Roman, Thomas Prossliner et al. · bioRxiv · 0 citations