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Resistance to antibacterial peptide nucleic acids through altered ribosome function

J. Frimodt-Møller I. M. Roman Thomas Prossliner L. Happonen K. L. Nielsen S. Häussler E. Rossi Michael O'Connor Peter E. Nielsen A. Løbner-Olesen

Sep 2026 · bioRxiv · 0 citations · 39 references

Biology

TL;DR

The ribosome–mRNA interface is identified as an intracellular determinant of antibacterial PNA susceptibility and rpsLI82N alters uS12-dependent 30S assembly and initiation-complex dynamics, thereby changing the effective occupancy of mRNA translation-initiation regions.

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