K. Mahajan

Aromatase inhibitors, GnRH analogues and growth hormone for short stature with advanced bone age in adolescent boys: a Bayesian network meta-analysis.

INTRODUCTION Adolescent boys presenting late with short stature and advanced bone age (BA/CA >1) have guarded height outcomes. Whether aromatase inhibitors (AI) or GnRH analogues (GnRHa) combined with growth hormone (GH) improve height is unknown. We compared AI+GH, GnRHa+GH, AI alone, and GH alone in boys with reduced...

World Journal of Nephrology

Aldosterone Synthase Inhibitors: Emerging Therapeutic Strategies in Resistant Hypertension

Resistant hypertension (RH) is a high-risk phenotype associated with increased cardiovascular and renal morbidity despite multidrug therapy. Dysregulation of the renin–angiotensin–aldosterone system (RAAS), particularly excess aldosterone activity, plays a central role in the pathophysiology of RH. Although conventiona...

β-Blocker Discontinuation after Myocardial Infarction without Reduced Ejection Fraction in the Revascularization Era: A Design-Coherent Bayesian Review & Meta-Analysis

In contemporary revascularized patients with preserved or mildly reduced EF, β-blocker discontinuation was not associated with a credible increase in death or MACE, whether stopped in the stable phase or the acute-withdrawal phase; the prior harm likely reflects immortal-time bias and inclusion of non-revascularized pa...

Beyond therapeutic maximalism: Prioritization and personalization in preventive therapies.

A Clinical Prioritization and Personalization Framework centered on individualized risk-based intensification, comprehensive residual risk management, and optimization of treatment delivery is proposed to achieve sustainable, patient-centered cardiovascular protection.