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Author

K. Ressler

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Open access Sep 2026

Epigenetic age acceleration is associated with brain connectivity changes and the risk of major depression after trauma

Background: Major depressive disorder (MDD) is associated with brain dysfunction and age-related diseases. Epigenetic clocks based on DNA methylation patterns estimate biological aging and aim to predict morbidity and mortality. Although MDD has been linked to epigenetic age acceleration (EAA) cross-sectionally, it is...

A. Navarro-Flores, Hazel Milla, S. Linnstaedt et al. · 0 citations
Open access Sep 2026

Whole-exome sequencing in individuals with obsessive-compulsive disorder and chronic tic disorders identifies 36 large-effect risk genes.

Obsessive-compulsive disorder (OCD) and chronic tic disorders (CTDs) are highly heritable. Rare mutations confer large risks for OCD and CTDs but only four high-confidence (hc) genes have been identified. Here we analyzed whole-exome sequencing data from 3,964 individuals with OCD, CTDs or both, including 2,418 trios....

Belinda Wang, M. N. Tran, Sheng Wang et al. · 0 citations
Open access Sep 2026

Alignment of natural language processing-derived RDoC scores with depression, anhedonia, and anxiety in psychiatric electronic health records

Clinical notes may provide useful information about dimensional psychiatric symptoms and could support scalable approaches to studying mental health, and NLP-derived RDoC scores may offer a scalable approach for characterizing dimensional psychopathology.

M. Kuhn, Seoin Ahn, V. Holstein et al. · 0 citations
Open access Jul 2026

Ancestry-Calibrated Polygenic Risk Scores Predict PTSD Trajectories in Recent Trauma Survivors and Interact with Neighborhood Resources

Objective: Polygenic risk scores (PRS) for posttraumatic stress disorder (PTSD) often account for a low amount of variance. Ancestry-related differences in PRS scale and variance limit cross-group comparisons. This methodological challenge further complicates gene-by-environment (GxE) analyses, given that socioenvironm...

E. Webb, Aarti Jajoo, Vijetha Balakundi et al. · 0 citations
Review Aug 2026

Towards precision psychiatry: initial foundations and future directions.

This Perspective discusses mechanistic approaches that focus on excitation-inhibition balance, reward and aversion circuits, hippocampal-prefrontal neuroplasticity, and processing of social cues, highlighting how these frameworks can elucidate drug mechanisms and predict treatment responses.

Amit Etkin, P. O’Donnell, K. Ressler et al. · 0 citations

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