Aug 2026· Nature reviews. Drug discovery· 0 citations· 186 references
Medicine
TL;DR
This Perspective discusses mechanistic approaches that focus on excitation-inhibition balance, reward and aversion circuits, hippocampal-prefrontal neuroplasticity, and processing of social cues, highlighting how these frameworks can elucidate drug mechanisms and predict treatment responses.
This review presents a conceptual framework for precision psychiatry that emphasizes multimodal approaches, and describes key sources of information, including demographic and psychosocial factors, as well as biological data, particularly neuroimaging, genetics, and molecular profiling.
Zui C. Narita, A. K. Mathur, Kun Yang· International Review of Psyc...· 0 citations
The review underscores the need for longitudinal research, refined diagnostic frameworks, and context-sensitive implementation strategies to advance holistic, patient-centered management of depression in schizophrenia.
Oshi Malik, Priyanka Yadav· Indian Journal of Medical Sp...· 0 citations
The latest developments in connectome-based modeling of the suicidal brain can not only inform neurobiological mechanisms but also help to advance clinical translation, and a novel paradigm using normative models to develop a connectome-based suicide risk calculator is proposed.
Kun Qin, Jun-Ni Ran, Nan-Fang Pan et al.· Biological Psychiatry· 0 citations
This review synthesizes current evidence on the unique pathophysiology, clinical management, and emerging frontiers of geriatric mental health, emphasizing the interplay of neurobiological aging, multimorbidity, and psychosocial stressors to advance precision psychiatry for LMDs.
Jin Wang, An-Qi Li· Frontiers in Psychiatry· 0 citations
A comprehensive report on the production of endogenous neurosteroids in the brain, the current clinical landscape for the use of neurosteroid-based therapies in psychiatry, and the potential utility of measuring neurosteroidogenesis capacity as a biomarker for the diagnosis and treatment of psychiatric illnesses is pro...
Tauryn Dargan, N. Walton, Jamie L. Maguire· Biological Psychiatry· 0 citations
It is argued that animal models are most informative when used to test specific, well-defined mechanistic hypotheses and when readouts are anchored to human-relevant biomarkers and neurophysiology, rather than interpreted as proxies for diagnostic categories.
Inga Dammann-Bawadkji, F. M. Leweke, Cathrin Rohleder· Pharmaceutical Medicine· 1 citation
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