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Author

Kaixiang Zhu

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Jul 2026

GRP75 sustains CD8+ T cell homeostasis and memory generation through ensuring mitochondrial fitness.

This work demonstrates that GRP75 deficiency disrupts CD8+ T cell fate, leading to defective T cell homeostasis and impaired memory differentiation, and establishes GRP75 as a pivotal mitochondrial checkpoint that coordinates metabolic state and functional fate in CD8+ T cells.

Fan Zhao, Pengfei Wang, Zejin Cui et al. · 0 citations

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