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GRP75 sustains CD8+ T cell homeostasis and memory generation through ensuring mitochondrial fitness.

Fan Zhao Pengfei Wang Zejin Cui Zhi-Shan Zhao Li-Ze Wu Rui Zhang Da-Lei Gao Jia-Yan Wu Y. Shao Xue-Xiao Jin Yadan Bai Kaixiang Zhu Lin-Rong Lu
Jul 2026 · Cell Death and Differentiation · 0 citations · 40 references
Medicine

TL;DR

This work demonstrates that GRP75 deficiency disrupts CD8+ T cell fate, leading to defective T cell homeostasis and impaired memory differentiation, and establishes GRP75 as a pivotal mitochondrial checkpoint that coordinates metabolic state and functional fate in CD8+ T cells.

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