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Astral data-independent acquisition-based quantitative proteomics combined with molecular validation suggest that mitochondrial OXPHOS remodeling and redox-associated pathways may contribute to the antitumor activity of melittin.
Melittin exhibits antitumor activity in cervical cancer models, yet the long non-coding RNA (lncRNA) response and associated regulatory networks remain poorly understood. Here, strand-specific RNA-seq data from melittin-treated and untreated U14 murine cervical cancer cells were analyzed to characterize melittin-respon...
ABSTRACT Chalkbrood, a destructive larval disease caused by the fungal pathogen Ascosphaera apis, causes substantial losses in apiculture. Although host–pathogen interactions in Apis mellifera larvae infected with A. apis have been investigated, immune defense mechanisms in the Asian honey bee Apis cerana remain unclea...
Microsporidia rely extensively on host resources, yet how parasite-derived microRNAs coordinate infection remains poorly understood. Here, we investigated the function of nce-miR-12220, a miRNA identified in Nosema ceranae spores, during infection of Apis mellifera workers. Target prediction, dual-luciferase assays, an...
Findings support a negative regulatory role of novel-miR0032-5p in CAT expression and indicate that lncRNA1386.1 participates in a candidate shared miRNA-responsive regulatory relationship.
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