Astral data-independent acquisition-based quantitative proteomics combined with molecular validation suggest that mitochondrial OXPHOS remodeling and redox-associated pathways may contribute to the antitumor activity of melittin.
Cervical cancer remains a major cause of cancer-related mortality worldwide, highlighting the need for strategies that may improve responses to conventional chemotherapeutics. Epigallocatechin gallate (EGCG), a green-tea polyphenol with diverse biological activities, has been investigated as a potential chemosensitizin...
Mehmet Emin Ayağ, M. Tuncer, Ş. Öztürk· Biomolecules· 0 citations
Aliflorin suppresses BC progression by inhibiting the HINT2/NLRP3 signaling pathway, suggesting HINT2 is a viable biomarker and Al a promising therapeutic agent for BC treatment.
Lung adenocarcinoma (LUAD) continues to present therapeutic challenges because of pathway redundancy and treatment resistance, underscoring the need for multi-target and systems-level strategies. Baicalein (BA), a flavonoid metabolite from
Scutellaria baicalensis
Georgi, shows antitumor potential, yet integrati...
Jia-Qian Yuan, Jia-Yan Zhong, Rui-Lin Chen et al.· Frontiers in Oncology· 0 citations
Narciclasine is a promising natural-product-derived lead compound for further preclinical evaluation in HELLS-associated CRC vulnerabilities and is associated with HELLS downregulation, DNA damage-associated signaling, and apoptosis in CRC cells.
Yoon-Mi Lee, Su-Min Han, G. Park et al.· Pharmaceuticals· 0 citations
OBJECTIVES
As a principal flavonoid glycoside derived from Glycyrrhiza uralensis, isoliquiritin (ISLT) has exerted notable anti-tumor activity in multiple solid malignancies including lung and liver cancers. This study aims to investigate the therapeutic effect and mechanism of ISLT on oral squamous cell carcinoma (OSC...
Yi-Wen Qin, Han Wu, Yin-Yu Wang et al.· Cellular Signalling· 0 citations
Breast cancer remains a major clinical challenge because of its molecular heterogeneity, therapeutic resistance, and disease recurrence. Melittin, the principal bioactive peptide of honeybee venom, exhibits antitumor activity in multiple experimental models; however, its early proteome-wide effects in breast cancer cel...
Jun-Ling Zhu, Wen-Hua Xu, He Zang et al.· Biology· 0 citations
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