Author

Kam W. Leong

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Review Sep 2026

Engineering Metal Nanomaterials for Precision Genetic Medicine

Genetic medicine has established a transformative paradigm for precision therapy. To date, most advances have relied on viral vectors and non‐viral lipidic and polymeric nanocarriers. Although metal nanomaterials have not achieved clinical approval for gene therapy, recent progress in precise synthesis and versatile...

Kai-Yuan Zheng, K. Leong · Advanced Functional Material... · 0 citations

#gene editing Open access Sep 2026

Intracranial delivery of neuron-preferential lipid nanoparticles for gene-editing activity in mouse brain

Lipid nanoparticles (LNPs) are promising non-viral vectors for central nervous system (CNS) gene therapy, but effective delivery is limited by the blood-brain barrier and cell-type specificity. Here, we combined intracranial delivery with high-throughput, cluster-based screening and machine learning to identify LNP for...

S. S. Cai, Cody Slater, Veronica E. Farag et al. · Cell Reports Physical Scienc... · 0 citations