Tumour-host crosstalk is an emerging hallmark of malignancy. It is increasingly recognised that cancer alters non-tumour bearing distant organs, with important consequences for disease progression and survival. Skeletal muscle loss, a defining feature of cancer-associated cachexia, contributes to morbidity and reduced...
Vassilis Papalazarou, Jack Coomes, L. Rossi et al.· bioRxiv· 0 citations
Reactive oxygen species (ROS) drive pro-tumorigenic signaling but also promote lipid peroxidation and ferroptosis, making ROS regulation critical during high oxidative stress stages of tumor progression, such as metastasis. Loss of the antioxidant TIGAR in pancreatic ductal adenocarcinoma (PDAC) cells raises ROS and en...
Eric C. Cheung, Meng-Han Wu, Wen-Chih Cheng et al.· Cell Reports· 0 citations
The conceptual advances that have reshaped cancer research — from somatic mosaicism, functional genomics and cancer stem cells to tumour metabolism, precision oncology and artificial intelligence — and consider which ideas transformed the field, which fell short of expectations, and what challenges remain.
A. Balmain, René Bernards, H. Clevers et al.· Nature Reviews. Cancer· 0 citations
Local and systemic effects of hepatocellular p53 activity and cholesterol during MASH development are investigated, suggesting that dietary cholesterol promotes detrimental overactivation of p53 in MASH and facilitates fibrosis within the liver and distal organs.
Celine I. Wittke, Dale M. Watt, L. Butler et al.· bioRxiv· 0 citations
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