The conceptual advances that have reshaped cancer research — from somatic mosaicism, functional genomics and cancer stem cells to tumour metabolism, precision oncology and artificial intelligence — and consider which ideas transformed the field, which fell short of expectations, and what challenges remain.
Keith T. Flaherty, MD, who began a 1-year term as president of the American Association for Cancer Research in April 2026, spoke with Cancer Discovery's Suzanne Rose about his work, what he sees as the most exciting advances in cancer research, and his vision for the future.
Simple Summary Cancer treatment guidelines are based on results from groups of patients and remain the foundation of cancer care. However, some patients, especially those with rare cancers or cancers that no longer respond to standard treatments, reach a point where guidelines provide no further treatment option. This...
J. Lisziewicz, Oliver Wueseke, F. Lori· Cancers· 0 citations
This review provides a comprehensive, updated, and comparative overview of PIK3CA biology, its molecular alterations across human cancers, their prognostic and therapeutic relevance, and the current development of treatments targeting the pathway activated by PIK3CA.
A. Ottaiano, C. Picone, M. Santorsola et al.· Cancers· 0 citations
