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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Karen Rex

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Open access Jul 2026

Property-Biased Covalent DNA-Encoded Library Screening Enabled the Discovery of AM-8719, A Structurally Novel, CNS-Penetrant KRAS G12C Inhibitor

Activating mutations in the Kirsten rat sarcoma (KRAS) gene are prevalent oncogenic drivers in nonsmall cell lung cancer (NSCLC). Patients harboring KRAS-mutant lung cancers frequently develop central nervous system (CNS) metastases. Although approved KRAS G12C inhibitors (i.e., sotorasib and adagrasib) show promising...

Slavko Rast, Marie Morgan-Fisher, Sarah D. Blomquist et al. · 1 citation
Open access Jul 2026

Expanding Addressable KRAS Mutations through the Structure- and Property-Based Design of Dual-State (GDP/GTP), Reversible Pan-KRAS Inhibitors

AM-2383 represents an important proof-of-concept that structural insights from prior covalent KRASG12C inhibitors can be leveraged in the design of efficacious and well-tolerated inhibitors of diverse KRAS mutations.

Ryan P. Wurz, Jennifer R. Allen, J. Allen et al. · 0 citations
Open access Jul 2026

Coordinated Immune Activation Following KRAS Inhibition in Syngeneic Models Reveals Molecular Pathways that Potentiate and Limit Antitumor Immunity

Using KRAS and MEK inhibition, the authors demonstrate altered neoplastic cell fates and immune functions of cDCs, T cells, and macrophages. Addition of KRAS inhibition to PD-1 blockade enhances T cell– and macrophage-mediated antitumor immunity.

Daniel R Lu, T. Osgood, Shining Ma et al. · 0 citations

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