Open access
Jul 2026
Structure-guided engineering of AI-derived adenine base editors for nuclear and mitochondrial DNA editing
The results demonstrate that structure-guided refinement of AI-designed deaminases can produce precise, versatile base editors for nuclear and mitochondrial genomes, expanding the research and therapeutic applications of genome editing toolkits.
Hye-Yeon Hwang, Nabukenya Mariam, Jiyeon Kweon et al.
· Nucleic Acids Research · 0 citations