Design of synthetic activators for programmable gene expression
Transcription factors control gene expression by recruiting transcriptional coactivators through intrinsically disordered transcriptional activation domains (TADs), whose weak and promiscuous interactions make it difficult to establish quantitative relationships between coactivator recruitment and transcriptional outpu...
Wei Chen, Ruopu Jiao, Brian Coventry et al.
· bioRxiv (Cold Spring Harbor... · 0 citations