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Kevin P. Larsen

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Open access Aug 2026

A structural bridge between dengue virus tandem xrRNAs facilitates coordination of exonuclease resistance

ABSTRACT Orthoflavivirus RNA genomes resist host 5′–3′ exoribonucleases to produce subgenomic flaviviral RNAs (sfRNAs). This resistance is conferred by exoribonuclease-resistant RNA (xrRNA) structures within the viral 3′ untranslated region that often occur in tandem, and whose function can be coupled. In dengue virus...

Elizabeth A. Spear, Z. O’Donoghue, Steve L. Bonilla et al. · 0 citations
Open access Jul 2026

Assembly and priming of the VPS4B AAA+ ATPase of the human ESCRT system

The cryo-electron microscopy structure of the full-length human VPS4B hexamer in six-membered helical “spiral staircase” states suggests a mechanism for substrate-dependent hexamerization and priming of VPS4 for its ESCRT-III remodeling activity.

James H. Hurley, Yu-Chao Zhang, Shuixia Tan et al. · 0 citations

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