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Kilian Declerck

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Sep 2026

Metal–Organic Framework Dimensionality and Interfacial Interactions Govern DNA Hydrolysis

Cleavage of phosphodiester bonds in DNA is a challenging yet essential reaction in many medical and biotechnological applications. This has motivated the development of synthetic catalysts that mimic nuclease reactivity while offering greater robustness, tunability, and cost-efficiency than natural enzymes. Three-dim...

Kilian Declerck, Nada D. Savić, Tatjana N. Parac-Vogt · 0 citations
#protein folding Open access Sep 2026

Folding within Frameworks: Confinement in Zr-MOFs Reshapes Enzyme Structure and Catalytic Activity

Enhancing the robustness of functional proteins remains a central challenge in biotechnology, with implications for catalysis, pharmaceuticals, and industrial synthesis. Enzyme immobilization in porous materials such as metal–organic frameworks (MOFs) is widely used to enhance enzyme stability; however, the structural...

Siene Swinnen, Maxim Lox, Marika Di Berto Mancini et al. · 0 citations

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