Divalent cation depletion enhances intrinsic neuronal excitability through CaSR-dependent modulation of threshold ion channels
It is confirmed that reducing [Ca2+]e or [Mg2+]e enhances intrinsic excitability and hyperpolarizes the AP threshold of CA1 pyramidal neurons, and that CaSR participate in the enhancement of intrinsic neuronal excitability induced by external divalent cation levels.
Konstantina Mylonaki, Matías Alvarez-Saavedra, Michaël Russier et al.
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