Author

Kun Lin

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Review Open access Sep 2026

Targeting subchondral osteoporosis in osteoarthritis: biomechanical crosstalk and the therapeutic rationale for inflammatory microenvironment remodeling

Current osteoarthritis (OA) management remains largely symptom-directed, while the contribution of osteoporosis (OP)-related and OA-associated subchondral remodeling to disease heterogeneity remains uncertain. This review integrates macroscopic load redistribution and lower-limb malalignment with local osteoimmune proc...

Ming-Li Han, Long-Fei Han, Su-Yan Zhang et al. · Frontiers in Immunology · 0 citations

#protein folding Open access Sep 2026

Integrative transcriptomics–metabolomics reveals sphingolipid metabolic reprogramming in traditional Chinese medicine syndrome differentiation of rheumatoid arthritis

C17-sphinganine is a core metabolic biomarker for distinguishing kidney-liver deficiency syndrome from heat-dampness syndrome, enabling precise syndrome classification with a single measurement.

Yao Li, Ying Wu, Jin-Xiang Zeng et al. · Frontiers in Immunology · 0 citations