In this study, we present the largest rare coding variant association study of schizophrenia to date, with 87,959 schizophrenia cases and 150,587 controls. We identify 16 genes at exome-wide significance: SETD1A, ZMYM2, HERC1, RB1CC1, SCAF1, XPO7, SP4, FYN, PPP3CA, CUL1, HDAC9, JARID2, ATP9A, PTK2, STAG1, and SCN2A, an...
J. Sealock, C. Dowd, Calwing Liao et al.· bioRxiv· 1 citation
Importance
Mental disorders are a leading cause of disability worldwide, and their burden continues to increase across Africa. Despite growing need, access to care remains limited, with treatment gaps reaching up to 90% in some settings. These gaps reflect longstanding constraints in workforce, financing, infrastructur...
R. P. F. Wolthusen, F. Jaguga, Linnet Ongeri et al.· JAMA psychiatry· 0 citations
Together, these results implicate a constellation of rare variants that map onto neuronal biology and demonstrate that diverse global populations converge on shared genetic signals underlying BD risk.
Calwing Liao, Robert Ye, J. Sealock et al.· medRxiv· 0 citations
Abstract Background Trauma exposure is a significant predictor of later psychopathology, including depression, anxiety, post-traumatic stress disorder (PTSD), and suicidality. Global evidence consistently demonstrates that individuals exposed to physical, sexual, or emotional abuse face increased risk of self-harm and...
C. Gumbo, Z. Kimari, F. Jaguga et al.· International Journal of Neu...· 0 citations
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