Author

L. Birkholtz

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#protein folding Oct 2026

Potent reaction hijacking inhibitors of Plasmodium falciparum asparagine tRNA synthetase

ABSTRACT Malaria remains one of the major threats to human health. Breakthrough drugs with high potency and low resistance risk are needed to combat the ever-increasing resistance to currently deployed antimalarials. Here, we explore a series of 4-aminoquinazoline-based sulfonamides (4AQS), with a synthetically accessi...

Xi Ye, Lisl Y. Esherick, Nutpakal Ketprasit et al. · mBio · 0 citations

Open access Sep 2026

Probing the activity of BM212, an antimycobacterial, and its derivatives against multiple life cycle stages of Plasmodium falciparum

The emergence of resistance to frontline antimalarial drugs underscores the urgent need for new chemotypes capable of targeting multiple P. falciparum life-cycle stages, including transmission stages. Building on the antimycobacterial scaffold BM212 , we generated and profiled a focused library of 1,3,5-...

Benedetta Salvucci, Mariëtte E. van der Watt, Chiara Tammaro et al. · Frontiers in Drug Discovery · 0 citations