L. Fang

Ancient introgression drives wild boar expansion and phenotypic diversification of domestic pigs.

Despite the ubiquity of wild boar populations across Eurasia, their origins, routes of dispersal, and phenotypic evolution remain uncertain. Here, using 745 genomes representing populations across Eurasia, we demonstrate that wild boar expanded from South Asia during the Middle Pleistocene. This expansion was preceded...

Multi-layer Cis-molQTLs Reveal Regulatory Architecture and Enhance Heritability Explanation for Complex Traits in Cattle.

Genome-wide association study (GWAS) analyses have identified numerous loci associated with economic traits in cattle. Many of these loci reside in noncoding regions, and the regulatory mechanisms through which they influence complex traits remain poorly understood. Here, we integrated 657 RNA-seq libraries from 275 Hu...

Pangenome Graph Reveals the Structural Variation Landscape in 2929 Cattle Samples and Its Impact on Gene Regulation.

High-fidelity pangenome graphs are constructed by integrating both assembly-based and whole-genome sequencing (WGS) derived SV catalogs and provide novel insights into the SV landscape and its contribution to gene regulation, underscoring its importance in cattle genetics and genomics.

Bridging precision agriculture and human medicine through comparative genetics.