Author

L. Gilbert

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Open access Aug 2026

SNHG family lncRNAs promote Ewing sarcoma cell fitness through intronic snoRNA-guided rRNA modifications

Abstract Over 90% of Ewing sarcomas (EWS) are driven by the EWS–FLI1 fusion oncoprotein. EWS–FLI1 acts as a pioneer transcription factor, altering the expression of hundreds of genes including many long non-coding RNAs (lncRNAs). The role of these lncRNAs in the oncogenesis of EWS is mostly unknown. We developed a CRIS...

Marcela Briones-Martin-Del-Campo, Alex G. Lee, Truc Dinh et al. · NAR Cancer · 0 citations

Open access Aug 2026

A Dimeric Protein-RNA Glue Promotes Multivalent eIF4A-RNA Assembly

BisRoc is identified, a dimeric rocaglate ligand that potently and durably suppresses translation and exhibits greater specificity across a cancer cell line panel than the monomeric RocA.

Jie Liu, Megan K. Moore, Kevin Lou et al. · ACS Central Science · 0 citations

#gene editing Open access Aug 2026

Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells.

A virus-like particle (VLP)-based toolkit that delivers diverse CRISPR editing modalities to human monocytes, macrophages and dendritic cells with high efficiency while preserving viability and innate immune responsiveness is presented.

Hyuncheol Jung, Pascal Devant, Carter Ching et al. · Nature Biotechnology · 0 citations