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Author

L. Happonen

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2 papers indexed here

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Open access Sep 2026

Molecular mechanism of complement interference by Streptococcus pyogenes nuclease A

Bacteria deploy virulence factors to subvert host immunity; yet the molecular details of these interactions often remain limited. Here, we reveal the structure and host interactome of the Streptococcus pyogenes nuclease A (SpnA). We characterize the structure and dynamics of SpnA using hydrogen-deuterium exchange mass...

Isabella A. Bennig, Joel Ströbaek, R. Mamede et al. · 0 citations
Open access Sep 2026

Resistance to antibacterial peptide nucleic acids through altered ribosome function

The ribosome–mRNA interface is identified as an intracellular determinant of antibacterial PNA susceptibility and rpsLI82N alters uS12-dependent 30S assembly and initiation-complex dynamics, thereby changing the effective occupancy of mRNA translation-initiation regions.

J. Frimodt-Møller, I. M. Roman, Thomas Prossliner et al. · 0 citations

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