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Author

L. Khoo

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Oct 2026

Aging-driven Mechanisms Underlying Parkinson's Disease Pathogenesis: Molecular, Cellular, and Systemic Perspectives.

Aging is a major risk factor for Parkinson's Disease (PD) and is linked to various biological processes at the molecular, cellular, and systemic levels. At the molecular level, aging-related oxidative stress, mitochondrial dysfunction, genetic factors, and impaired proteostasis contribute to dopaminergic neuronal death...

A. Lee, L. Khoo, Khuen Yen Ng et al. · 0 citations
Review Jul 2026

From synaptic development to degeneration: a narrative review of small molecule strategies targeting alpha-synuclein in Parkinson’s disease

In conclusion, small-molecule-based therapies represent a promising multi-targeted strategy for PD; however, key translational challenges and unresolved questions remain, including optimisation of pharmacokinetics, target specificity, and blood-brain barrier penetration and validation in clinical settings.

L. Khoo, K. Ng, Cien Leong Chye et al. · 0 citations

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