Author

L. N. van de Lagemaat

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Open access Sep 2026

The obesity associated BDNF intron-3 cis-regulatory element, BE5.1, modulates the effects of early-life stress on weight gain, anxiety and gene expression in a sex-dependent manner

Results suggest that the BE5.1CRE acts as a buffer element that protects against the maladaptive effects of MS on gene expression and later life behaviours in a sex-dependent manner.

A. McEwan, Joseph Morgan, Greg Hutchings et al. · bioRxiv · 0 citations

Open access Aug 2026

RNA terminal uridylyl transferases are druggable vulnerabilities in AML but are dispensable for normal hematopoiesis

Together, these findings identify TUT4/7 as druggable targets, whose inactivation suppresses AML while sparing normal hematopoiesis, and represents a promising therapeutic strategy in combination with venetoclax.

Christopher Mapperley, Elise Georges, A. Azar et al. · Science Advances · 0 citations

Review Open access Jul 2026

Large-scale dimensional behavioral profiling dissociates fear memory from locomotor confounds in mice: The necessity of baseline-normalized metrics

It is shown that baseline locomotor normalization is essential for interpreting fear conditioning as a memory assay and provide an open framework for selecting and reporting locomotor-normalized metrics.

Daiki X. Sato, M. M. Chatzigiannis, Hirotaka Shoji et al. · bioRxiv · 0 citations