The obesity associated BDNF intron-3 cis-regulatory element, BE5.1, modulates the effects of early-life stress on weight gain, anxiety and gene expression in a sex-dependent manner

Identification of genes and pathways associated with chronic restraint stress-induced anxiodepressive-like behaviors in female mice by transcriptomic and genome-wide DNA methylation combinational-analysis.

It is suggested that CRS-induced DNA hypermethylation at CG and CHH sites in the female mPFC may contribute to stress-induced transcriptional dysregulation, potentially driving anxiodepressive-like behaviors.

Prenatal Ethanol Exposure and Adolescent Stress Are Associated, in Male Rats, with a Compulsive-Like Phenotype and Alterations in Microbiota Composition and Neuroimmune Gene Expression.

Prenatal ethanol exposure (PEE) alters neurobehavioral function, yet the factors associated with these effects, particularly in interaction with stress, remain poorly understood. We examined whether combined exposure to PEE and adolescent restraint stress altered compulsive-like behavior and, in the sex showing the cle...

Sex differences and sex-dependent effects of maternal immune activation and raloxifene on neurotransmitter gene expression in the adult rat dorsal striatum.

The importance of sex as a biological variable is highlighted and candidate molecular pathways through which prenatal immune insult and estrogen receptor modulation may influence vulnerability and treatment response in neurodevelopmental disorders are identified.

Environmental enrichment differentially suppresses anxiety-related behaviors, reduces passive avoidance learning, and upregulates hippocampal brain-derived neurotrophic factor expression in high- and low-avoidance Hatano rats.

Anxiety disorder risk is influenced by both adverse environmental factors and genetic background. We previously described high-avoidance animal (HAA) and low-avoidance animal (LAA) strains of male Hatano rats that may provide robust models for assessing interactions between genetic background and environment driving an...

The serotonin transporter genotype x cumulative early-life stress interaction has opposite effects on anxiety-like behaviors in male and female rats

Differential physiological, behavioral, and medial prefrontal cortex transcriptomic responses to chronic restraint stress between BALB/c and C57BL/6J mice

Chronic stress is a major risk factor for psychiatric disorders such as depression and anxiety, yet the biological basis of individual differences in stress susceptibility and resilience remains poorly understood. Here, we examined physiological, behavioral, and medial prefrontal cortex (mPFC) transcriptomic responses...