L. Portengen

The occupational exposome and new-onset COPD: longitudinal analyses of two European cohorts.

OBJECTIVES Occupational exposures may contribute to the development of COPD, a leading cause of morbidity and mortality globally. Using an exposome approach in a follow-up design, we aimed to examine the association between the occupational exposome and new-onset COPD in 2 population-based cohorts: the European Communi...

Cytokine Concentrations in Workers Exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Changes in plasma levels of a large panel of cytokines, chemokines, and growth factors among workers from a Dutch historical cohort occupationally exposed to chlorophenoxy herbicides and contaminants including TCDD suggest that TCDD exposure could suppress the immune system and that chemokine and growth factor-dependen...

of Dutch chlorophenoxy herbicide manufacturing workers

Exploring molecular signatures of exposure to water disinfection by-products: A multi-omic analysis across multiple exposure routes.

BACKGROUND Disinfection by-products, including those arising from secondary reactions between chlorinated reagents and natural organic matter such as trihalomethanes (THMs), have been associated with several adverse health outcomes, such as bladder and colorectal cancer. AIMS We aim to identify metabolic signatures o...