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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

L. Su

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2 papers indexed here

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Open access Aug 2026

Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy

Tregs engineered with an orthogonal IL-2 tethered to its receptor persisted without exogenous IL-2 and exhibited superior therapeutic efficacy in a mouse model of type 1 diabetes.

Alyssa C. Indart, Huiyun Lyu, V. Nguyen et al. · 0 citations
Open access Aug 2026

A Cytokine Receptor Signaling Atlas Reveals How STAT Mosaics Fine-Tune T Cell Function

The extent to which JAK/STAT cytokine signaling is functionally redundant or selective remains debated. Here we engineered a “double” orthogonal IL-2/IL-2Rβ/γc ternary system enabling programmable, interference-free activation of each of the 36 mammalian cytokine receptors, and their downstream six STATs, in T cells. A...

Pingdong Tao, Ruchir Rastogi, Hua Jiang et al. · 0 citations

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