Open access
Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy
Alyssa C. Indart
Huiyun Lyu
V. Nguyen
Wendy Rosenthal
Jatin R. Palvai
Sophie S. Jang
Yue Chen
K. Jude
L. Su
K. Garcia
J. Bluestone
Qi-Zhi Tang
Medicine
Abstract
Tregs engineered with an orthogonal IL-2 tethered to its receptor persisted without exogenous IL-2 and exhibited superior therapeutic efficacy in a mouse model of type 1 diabetes.