Sep 2026
RNA Splicing of the REST Gene by SRRM4 in Vascular Smooth Muscle Cells Promotes Abdominal Aortic Aneurysm Development
Y. Li, Y. Wang, Q. Ni et al.
· medRxiv · 0 citations
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Aug 2026
Polygenic Risk Scores for Cardiovascular Disease Predict Risk Factor Control and Residual Cardiovascular Risk in Stroke Survivors
Background: Stroke remains a leading cause of mortality and long-term disability worldwide, with high residual vascular risk among survivors despite optimal secondary prevention. The contribution of inherited polygenic risk to this residual vulnerability remains unclear. Methods: We analyzed 2,701 stroke survivors (mea...
N. Bragazzi, L. Zhang, M. Omarov et al.
· medRxiv · 0 citations
Paired plaque and plasma proteomics reveal molecular signatures of symptomatic atherosclerosis
Deep proteomic profiling of human carotid plaques identifies molecular signatures of symptomatic atherosclerosis that extend beyond conventional histopathology, which implicate neutrophil activation and inflammatory signaling pathways as key determinants of plaque vulnerability.
L. Zhang, L. Živković, A. Ray et al.
· medRxiv · 0 citations