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Author

Lasse Middendorf

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Review Open access Jul 2026

Generative artificial intelligence for enzyme design and biocatalysis.

It is argued that generative AI models now have the maturity to create and optimize enzymes for industrial applications and can speed up the development of biocatalysts and serve as a community assessment to inform the next generation of models.

Lasse Middendorf, Noelia Ferruz · 1 citation
Open access Aug 2026

A discrete protein subset drives structure prediction discordance in orphan proteins

The discordance persists: pLDDT correlates positively with PUNCH2 disorder in random and de novo proteins and negatively with β-strand fraction, opposite to the conserved and disordered baselines, a concrete failure mode that protein designers and other working on sequences remote in sequence space should be aware of w...

Lars A. Eicholt, Lasse Middendorf · 0 citations

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