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SynFarsa is characterized, a synthetic circRNA-derived IRES-like element that promotes cap-independent translation in mouse and human cells and provides a circRNA-derived effector domain for targeted translational upregulation of an endogenous protein.
The RNA-DNA interactome is established as a new genome regulatory layer that defines and maintains cellular identity and behavior and is shown to be highly dynamic yet reproducibly organized in cell-type specific networks.
This work examines the physicochemical principles underlying RNA-mediated crowding, focusing on how sequence-driven multivalency, structural topology, and network connectivity govern molecular organization.
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