Author

Lee-Way Jin

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Open access Sep 2026

Cardiovascular risk factors and regional neuropathology in autopsy-confirmed Alzheimer disease.

Cardiovascular risk factors are implicated in Alzheimer disease (AD) progression and its neuropathological hallmarks but their specific contributions to regional brain pathology within AD remain understudied. In this cohort study (n = 276), we examined associations between diabetes, hypertension, and hypercholesterolem...

David Garcia, Hsin-Pei Wang, Naomi Saito et al. · Journal of Neuropathology an... · 0 citations

Open access Sep 2026

Regional distribution of mineralized blood vessels in Alzheimer disease and clinicopathological associations: A multicenter autopsy study.

Mineralized blood vessels (MBV) are a form of vascular pathology associated with cerebrovascular aging and neurodegeneration; however, their regional distribution and clinicopathological correlates in Alzheimer disease (AD) remain poorly characterized. We examined 265 decedents with intermediate/high AD neuropathologic...

David Garcia, Naomi Saito, Shyam Tamizharasu et al. · Neurobiology of Aging · 0 citations

#protein folding Open access Aug 2026

Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations

A scalable, open-source, deep-learning approach to quantify NFT burden in digital whole slide images (WSIs) of post-mortem human brain tissue and openly releases this multi-institution deep-learning pipeline to provide detailed NFT spatial distribution and morphology analysis capability at a scale otherwise infeasible...

S. Ghandian, Liane Albarghouthi, Kiana Nava et al. · Scientific Reports · 0 citations