Review
Jul 2026
Multifactorial Regulation of Inflammatory Bone Loss in Chronic Inflammatory and Immune-Associated Disorders: Osteoimmune Mechanisms and Translational Prospects of Natural Small Molecules
The osteoimmune mechanisms through which persistent inflammation disrupts coupled bone remodeling are synthesized, with emphasis on RANKL-dependent osteoclastogenesis, suppressed osteoblast-supportive signaling, cytokine networks, immune-cell plasticity, and lesion microenvironment.
Juhao Pi, Bo-Lei Li, Qiang-Zhong Pi et al.
· Calcified Tissue Internation... · 0 citations