Multifactorial Regulation of Inflammatory Bone Loss in Chronic Inflammatory and Immune-Associated Disorders: Osteoimmune Mechanisms and Translational Prospects of Natural Small Molecules
The osteoimmune mechanisms through which persistent inflammation disrupts coupled bone remodeling are synthesized, with emphasis on RANKL-dependent osteoclastogenesis, suppressed osteoblast-supportive signaling, cytokine networks, immune-cell plasticity, and lesion microenvironment.
A structured research roadmap is proposed—centered on fate-mapping, lineage-specific depletion, and single-cell multi-omics—to convert the prevailing hypothesis into experimentally testable and clinically actionable evidence, while delineating the translational challenges that must be overcome to achieve precision seno...
Min-Shun Zhu, Jie Zhang, Hou-Shan Fang et al.· Frontiers in Endocrinology· 0 citations
Background Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass, impaired microarchitecture, and increased fracture risk. Patients with immune-mediated inflammatory diseases (IMIDs) have a higher prevalence of osteoporosis owing to chronic inflammation, glucocorticoid use, and disease-specifi...
Isabel de la Cámara-Fernández, T. Cobo-Ibáñez, Olga María Reillo-Sánchez et al.· Frontiers in Medicine· 0 citations
A narrative synthesis of current evidence about the molecular mechanisms by which T-cell subsets regulate osteoporosis-related bone remodeling, the features of immune imbalance in different types of osteoporosis, T-cell-targeted intervention strategies, and translational challenges is provided to provide a theoretical...
Yuan Gong, Wen-Xing Zeng, Yi-Tao Liao et al.· Frontiers in Immunology· 0 citations
Abstract Osteoporosis has traditionally been viewed as a bone remodeling disorder characterized by excessive bone resorption and inadequate bone formation. However, this paradigm does not fully explain its systemic heterogeneity, persistent progression, or variable therapeutic responses. This review reconceptualizes os...
Yu-Chang Ma, Shi-Yu Tian, Yao-Wen Zhang et al.· International Journal of Gen...· 0 citations
Osteoporotic fractures are traditionally regarded as severe clinical consequences of low bone mass and impaired bone strength, but fracture risk and repair outcomes are also shaped by systemic inflammation, intestinal barrier integrity, microbial metabolism, and osteoimmune regulation. Increasing evidence indicates tha...
Zi-Xin Xu, Shu-Tao Jin, Yi-Ze Liu et al.· Frontiers in Immunology· 0 citations
Bone metabolic disorders, such as osteoporosis, osteoarthritis, and rheumatoid arthritis, are characterized by disrupted skeletal homeostasis and represent major challenges in musculoskeletal health. Bone remodeling has long been interpreted as a coordinated process between osteoblast-mediated bone formation and osteoc...
Chang-Shun Huang, Shou-Xiang Kuang, Xi Chen et al.· Frontiers in Immunology· 0 citations
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