BACKGROUND
The precise molecular delineation of the interface between the Subiculum (Sub) and cornu ammonis 1 (CA1) is a challenge in hippocampal research, as conventional cytoarchitectural boundaries are often ambiguous and limit reproducible regional annotation. Here, we developed a molecularly anchored spatial trans...
Fullscope-seq resolved hundreds of major isoform switches across distinct brain regions and identified DTUs between superficial and deep cortical layers and showed substantial enrichment for neuropsychiatric disorder-associated genes.
Hengxin Liu, Yanhong Hong, Y. Zhang et al.· Nature Methods· 0 citations
A comprehensive transcriptomic and chromatin accessibility atlas of 8 brain regions of 23 female cynomolgus macaques spanning the adult lifespan, including exceptionally old individuals establishes a foundational framework for understanding the cellular and regulatory architecture of primate brain aging and its links t...
Together, gene expression-defined cortical layers (GD-Ls) provide an objective and reproducible tool for standardized cortical mapping and for identifying early pathological signatures in the human brain.
Yanrong Wei, Youzhe He, Yuyang Liu et al.· Genome Medicine· 0 citations
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