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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Lei Huang

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2 papers indexed here

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Sep 2026

Dilution mode acts as a critical process parameter that reprograms lipid nanoparticle assembly and in vivo mRNA delivery.

Messenger RNA (mRNA)-loaded lipid nanoparticles (LNPs) are predominantly manufactured by microfluidic mixing, where extensive efforts have focused on optimizing upstream formulation and mixing parameters. In contrast, the influence of dilution methods on the final physicochemical properties and biological performance o...

Si-Yuan Tang, Lei Huang, Wu Wang et al. · 0 citations
#gene editing Open access Aug 2026

Elucidate the structural role of helper lipids in modulating hepatic expression following repeated intravenous administration of mRNA-LNPs

Lipid nanoparticles (LNPs) are the most advanced non-viral platform for hepatic mRNA delivery, yet the functional role of helper phospholipids, particularly under repeated dosing regimens required for chronic protein replacement therapies, remains poorly understood. Here, we systematically investigated six helper phosp...

Jia-Hao Ge, Xiaochen Bo, Xinye Zhu et al. · 1 citation

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