Disrupting the MYB–TAL1 oncogenic axis via direct intracellular delivery of synthetic zinc finger proteins
T-cell acute lymphocytic leukemia (T-ALL) protein 1 (TAL1) is an important transcription factor in the specification of myeloid cells and positively regulates the differentiation of red blood cells. Aberrant, high-level expression of TAL1, mediated by insertions of short DNA sequences that recruit the transcription fac...
Matthew D. Gibbons, Jörg Bungert, Vincent Nganga et al.
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