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Author

Leticia Guzmán Ruiz

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Open access Oct 2026

Spatial transcriptomics reveals early immune responses in HIV and tuberculosis coinfection in humanized mice

Mycobacterium tuberculosis (Mtb) and human immunodeficiency virus (HIV) coinfection is a major public health concern, yet early immune and tissue changes during coinfection remain incompletely understood. Here we show, using a humanized mouse model and spatial transcriptomics of lung tissue, that early immune cell...

S. Adduri, J. Bohórquez, Rajesh Mani et al. · 0 citations
Aug 2026

Genomic Characterization and Therapeutic Potential of the Lytic Bacteriophage Curly against Klebsiella pneumoniae in Human Innate Immune Cells and a Murine Pneumonia Model

Findings identify Curly as a promising bacteriophage candidate against K. pneumoniae and support further evaluation of its host range, resistance profile, and therapeutic potential.

Mounika Duggineni, S. Adduri, Rajesh Mani et al. · 0 citations

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