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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Li He

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Open access May 2026

Recovery of proofreading-impaired SARS-CoV-2 reveals a mutator phenotype and an ExoN activity threshold for viability

This work indicates that SARS-CoV-2 can tolerate substantial impairment of proofreading but only when residual exonuclease activity remains above a minimal threshold, and defines this activity threshold to help guide antiviral strategies that target coronavirus proofreading.

Li He, Yuan-Wei Norman Su, Fushun Zhang et al. · 0 citations
#protein folding Open access Aug 2026

Scarless SARS-CoV-2 Genome Engineering and Variant Analysis

A genome engineering technology is used to change a single amino acid in the viruses’ main protease enzyme to match that of circulating Omicron isolates to demonstrate antiviral efficacy of approved drugs and uncover mutants with reduced drug sensitivity.

Agnieszka Dabrowska, Ashley Cuell, Rahul Basu et al. · 0 citations

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