Preclinical proof-of-concept for a rationally designed CAR4-NK therapy against CLDN18.2-positive gastric cancer, in which CD28H-2B4 co-stimulatory domains enhance the effector function of CAR4-NK cells, and show the potential of irradiated CAR4-NK cells as a safer, controllable "off-the-shelf" product candidate.
A review of immunopathogenesis and therapeutic gaps in representative autoimmune diseases, compares CAR-T applications in malignancies and autoimmunity, and evaluates emerging response endpoints, target-selection strategies, and safety considerations in autoimmune settings suggests CAR-T therapy offers a potential stra...
Mengting Zhang, Lianfeng Zhao, Tianyu Chen et al.· International Immunopharmaco...· 0 citations
This review systematically delineates the mechanisms underlying bidirectional immune rejection and comprehensively summarizes state-of-the-art mitigation strategies and highlights the development of alternative, inherently hypoimmunogenic cell sources as a fundamental approach to circumventing these immunological barri...
Lu Ding, Lianfeng Zhao, Mengting Zhang et al.· Biochimica et biophysica act...· 0 citations
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