Author

Lin Liu

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Jul 2026

A low-cost CHA-integrated CRISPR/Cas12a-based test strip platform for on-site gene detection.

A novel nucleic acid detection platform that integrates catalytic hairpin assembly with the CRISPR/Cas12a system and utilizes pregnancy test strips for result visualization is developed, addressing the limitations of existing nucleic acid detection methods in balancing sensitivity, specificity, and portability with cos...

Huimin Wang, Lin Liu, Chengxin Bao et al. · Lab on a Chip · 0 citations

#protein folding Open access Aug 2026

Catalytic Hairpin Assembly-Aided CRISPR/Cas-SERS for Nucleic Acid Detection Enhanced by Multiple Catalytic Amplification

Owing to the collateral trans-cleavage activity of Cas12a and the high peroxidase-like nanozyme activity of G4/Hemin, this method achieves the highly sensitive SERS detection of genetically modified samples without target gene preamplification.

Lin Liu, Chengxin Bao, Huimin Wang et al. · ACS Measurement Science Au · 0 citations